MTHFR

Explanation of MTHFR genetic testing:

The MTHFR gene plays a key role in how our body processes folic acid, turning it into a form called L-methylfolate. This process is crucial because L-methylfolate is the active form of folate that circulates in our blood and supports several important functions in the body, including brain health and mood regulation.

Sometimes, due to genetic variations, some individuals have a version of the MTHFR gene that doesn't work as efficiently. These variations, particularly known as 677C>T and 1298A>C polymorphisms, can slow down the conversion of folic acid into L-methylfolate. This means that people with these variations might not produce enough L-methylfolate naturally, which is essential for creating neurotransmitters like serotonin, dopamine, and norepinephrine. These neurotransmitters are critical for regulating mood, and their production can be directly affected by the levels of L-methylfolate in the body.

By testing for these specific genetic variations, we can identify if you're likely to have this reduced enzyme activity. If so, supplementing with L-methylfolate can be particularly beneficial. This supplementation effectively bypasses the body's less efficient conversion process, providing the active form of folate directly. This can help enhance the production of vital neurotransmitters, potentially improving mood and contributing to better mental health outcomes, especially in individuals who are predisposed to depression or other mood disorders due to these genetic factors.

In summary, the test for the MTHFR gene's variations helps us tailor a treatment approach that could include L-methylfolate supplementation, ensuring your body receives the active form of folate it needs for optimal mental health and well-being.

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Written by:

Joseph Gagnon Jr.