Conditions That Can Benefit From Low-Dose Naltrexone (LDN)
- Kevin Keane
- Sep 26, 2024
- 5 min read
• Cardiac Diseases:
o Autoimmune cardiomyopathy
o Autoimmune myocarditis
o Autoimmune thrombocytopenic purpura
o Congenital heart block
o Coxsackie myocarditis
o Dressler's syndrome (postmyocardial infarction syndrome)
o Giant cell myocarditis
o Kawasaki disease
o Polyarteritis nodosa
o Postpericardiotomy syndrome
o Subacute bacterial endocarditis (SBE)
o Vasculitis
• Chronic Pain:
o Complex Regional Pain Syndrome/RSD
o Diabetic Neuropathy
o Migraines
o Peripheral neuropathy
o Temporomandibular joint disorder
• Dermatologic Disorders:
o Alopecia areata
o Alopecia universalis
o Amyopathic Dermatomyositis
o Anti-synthetase syndrome
o Atopic allergy
o Atopic dermatitis
o Autoimmune progesterone dermatitis
o Autoimmune urticaria
o Bechet’s syndrome
o Benign mucosal pemphigoid
o Blau syndrome
o Bullous pemphigoid
o Cicatricial pemphigoid
o Cutaneous leukocytoclastic angiitis
o Darier Disease
o Dego's disease (thrombotic vasculopathy)
o Dercum's disease (adiposis dolorosa)
o Dermatitis herpetiformis
o Dermatomyositis
o Diffuse cutaneous systemic sclerosis
o Discoid lupus erythematosus
o Eczema
o Epidermolysis bullosa acquisita
o Erythema nodosum
o Erythmodermic psoriasis
o Essential mixed cryoglobulinemia
o Familial cold autoinflammatory syndrome (FCAS)
o Frontal Fibrosing Alopecia (FFA)
o Hailey-Hailey Disease
o Herpes gestationis/pemphigoid gestationis (PG)
o Hidradenitis Suppurativa (HS) (Acne Inversa)
o Lichen planus
o Lichen sclerosus
o Linear IgA disease (LAD)
o Majeed syndrome
o Morphea
o Mucha-Habermann disease, PLEVA (pityriasis lichenoides et varioliformisacuta)
o Myositis
o Neonatal lupus
o Parry Romberg syndrome
o Pemphigus vulgaris
o POEMS syndrome
o Progesterone dermatitis
o Psoriasis
o Pyoderma gangrenosum
o Schnitzler syndrome
o Schulman disease
o Subacute cutaneous lupus erythematosus (SCLE)
o Sweet's syndrome
o Topical Steroid Withdrawal (TSW)
o Vitiligo
o Vogt-Koyanagi-Harada Disease
• Ear, Nose, Sinus, and Throat:
o Autoimmune inner ear disease (AIED)
o Burning mouth syndrome
o Churg-Strauss syndrome
o Cogan syndrome
o Ménière's disease
o Susac's syndrome
• Endocrine Disorders:
o Addison's disease
o Autoimmune polyendocrine syndrome
o Cushing's syndrome
o Diabetes mellitus type 1
o Eosinophilic esophagitis (EoE)
o Glycogen storage disorder (GSD VII)
o Graves' disease
o Hashimoto's thyroiditis
o Hypoglycaemia
o Hypopituitary or Secondary adrenal insufficiency
o Hypothalamic Dysfunction
o Hypothyroidism
o Juvenile diabetes (Type 1 diabetes)
o Ord’s thyroiditis
o Pituitary dysfunction
o POEMS syndrome
o Polyglandular syndromes type I, II, III
o Schmidt syndrome
o Thyroid eye disease (TED)
o Thyroiditis
• GI Disorders:
o Autoimmune hepatitis
o Autoimmune enteropathy
o Autoimmune pancreatitis
o Celiac disease
o Churg-Strauss syndrome
o Crohn’s disease
o Eosinophilic gastroenteritis
o Gastritis
o Gastrointestinal pemphigoid
o Gastroparesis
o Gluten sensitivity
o Gut dysbiosis
o Inflammatory bowel disease (IBD)
o Irritable bowel syndrome (IBS)
o Lupoid hepatitis
o Nonalcoholic steatohepatitis (NASH)
o Mesenteric Panniculitis
o POEMS syndrome
o Polyarteritis nodosa
o Primary biliary cirrhosis
o Primary sclerosing cholangitis
o Pyoderma gangrenosum
o Small intestinal bacterial overgrowth (SIBO)
o Schnitzler syndrome
o Ulcerative colitis (UC)
• Hematologic Disorders:
o Agammaglobulinemia
o Antiphospholipid syndrome
o Autoimmune aplastic anemia
o Autoimmune hemolytic anemia
o Autoimmune lymphoproliferative syndrome
o Castleman's disease (CD) – lymph node hyperplasia
o Cold agglutinin disease
o Evans syndrome
o Hemolytic anemia
o Henoch-Schonlein purpura (HSP)
o Immune thrombocytopenic purpura (ITP)
o Kawasaki disease
o Majeed syndrome
o Microscopic polyangiitis
o Monoclonal gammopathy of undetermined significance (MGUS)
o Myelodysplastic syndromes
o Neutropenia
o Paroxysmal nocturnal hemoglobinuria (PNH)
o Pernicious anemia (PA)
o POEMS syndrome
o Pure red cell aplasia (PRCA)
o Raynaud’s phenomenon
o Thrombocytopenic purpura (TTP)
• Hepatology:
o Hepatitis C
o Primary Biliary Cholangitis
• Immunology:
o Amyloidosis
o Autoimmune angioedema
o Common Variable Immunodeficiency
o Epstein Barr Virus
o IgG4-related sclerosing disease
o Juvenile myositis (JM)
o Mast cell activation syndrome (MCAS)
o Mold toxicity
o Pernicious anemia (PA)
o Vitiligo
• Infectious Diseases:
o Chagas disease
o Complement component 2 deficiency – increase risk of infections
o COVID
o Coxsackie myocarditis
o Herpes
o Herpes Zoster (Shingles)
o HIV/AIDS
o Hypogammaglobulinemia – leads to infections
o Long COVID
o Lyme Disease
o PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections)
o Sydenham chorea
• Cancers/Malignancies:
o Adenoid Cystic Carcinoma
o Bladder Cancer
o Breast Cancer
o Carcinoid Colon & Rectal Cancer
o Cholangiocarcinoma
o Colon Cancer
o Esophageal carcinoma
o Glioblastoma
o Glioma
o Hepatoblastoma
o Leukemia
o Liver cancer
o Lung cancer (Non-small cell)
o Lymphocytic leukemia (chronic)
o Lymphoma (Hodgkin's and Non-Hodgkin's)
o Malignant melanoma
o Mesothelioma
o Multiple myeloma
o Neuroblastoma
o Ovarian cancer
o Pancreatic cancer
o Parotid carcinoma
o Prostate cancer (untreated)
o Renal cell carcinoma
o Throat cancer
o Uterine cancer
• Neurologic Disorders:
o Achalasia
o Acute disseminated encephalomyelitis
o Acute hemorrhagic leukoencephalitis
o Alzheimer's
o Amyotrophic Lateral Sclerosis (ALS)
o Anti-mag IgM peripheral neuropathy
o Arachnoiditis
o Autism
o Autoimmune dysautonomia
o Autoimmune encephalomyelitis
o Autoimmune peripheral neuropathy
o Axonal & neuronal neuropathy (AMAN)
o Baló disease/Baló concentric sclerosis
o Bickerstaff's encephalitis
o Brain fog
o Charcot-Marie-Tooth syndrome
o Chronic inflammatory demyelinating polyneuropathy (CIDP)
o Crackly brain middle ear myoclonus (MEM)
o Cranial arteritis
o Devic’s disease (neuromyelitis optica)
o Duchesne Muscular Dystrophy
o Dystonia
o Electromagnetic hypersensitivity
o Guillain-Barré syndrome
o Hashimoto's encephalitis
o Idiopathic inflammatory demyelinating diseases
o Inflammatory demyelinating disease (IDD)
o Lambert-Eaton myasthenic syndrome (LEMS)
o Meniere's disease
o Miller Fisher syndrome (MFS)
o Mixed connective tissue disorder
o Multiple sclerosis (MS)
o Myasthenia gravis
o Myoclonic epilepsy
o Opsoclonus myoclonus syndrome
o Parkinson's Disease
o Peripheral neuropathy
o POEMS Syndrome
o Polyarteritis nodosa
o Pseudotumor cerebri
o Restless leg syndrome
o Spinal muscular atrophy
o Stiff-person syndrome
o Subacute combined degeneration
o Susac's syndrome
• Rheumatology Disorders:
o Ankylosing spondylitis
o Antiphospholipid syndrome
o Autoimmune autonomic ganglionopathy
o Bicipital tendinitis
o Chondritis
o Chronic Fatigue Syndrome (CFS) / Myalgic Encephalomyelitis (ME)
o Dermatomyositis
o Ehlers-Danlos Syndrome (EDS)
o Enteropathic arthritis
o Eosinophilic fasciitis
o Fibromyalgia
o Giant cell arteritis
o Granulomatosis with polyangiitis (Wegener's)
o Henoch-Schonlein purpura
o Hypermobility spectrum disorder
o Hypersensitivity vasculitis
o Inclusion body myositis
o Juvenile idiopathic arthritis (JIA)
o Kikuchi-Fujimoto disease
o Lupus nephritis
o Mixed connective tissue disease (MCTD)
o Osteoarthritis
o Polymyalgia rheumatica (PMR)
o Polymyositis
o Psoriatic arthritis
o Reactive arthritis (Reiter's syndrome)
o Relapsing polychondritis
o Rheumatic fever
o Rheumatoid arthritis (RA)
o Sarcoidosis
o Sjögren's syndrome
o Spondyloarthropathy
o Still's disease (adult-onset)o Systemic lupus erythematosus (SLE)
o Systemic sclerosis (scleroderma)
o Takayasu arteritis
o Undifferentiated connective tissue disease (UCTD)
o Vasculitis
• Urologic & Reproductive Disorders:
o Asherman’s syndrome
o Autoimmune orchitis
o Chronic pelvic pain syndrome
o Chronic prostatitis
o Endometriosis
o Interstitial cystitis (IC)
o Polycystic ovarian syndrome (PCOS)
o Premature ovarian failure
o Vulvodynia
• Other Conditions:
o Autoinflammatory syndromes
o Behçet's disease
o Chronic Lyme Disease
o Chronic Sinusitis
o Chronic Urticaria
o Hyper IgD syndrome (HIDS)
o Hypersensitivity pneumonitis
o Immunoglobulin G4-related disease (IgG4-RD)
o Kikuchi disease
o Macrophage activation syndrome
o Mastocytosis
o Mixed cryoglobulinemia
o Relapsing polychondritis
o Schnitzler syndrome
o Undifferentiated autoinflammatory disorder
This list includes various conditions across multiple specialties, demonstrating the wide-ranging potential applications of Low Dose Naltrexone (LDN) in treating both autoimmune and inflammatory diseases, as well as chronic pain and other disorders.